By Mitsuru Wada (auth.), Satoshi Matsumoto M.D., Kiyoshi Sato M.D., Norihiko Tamaki M.D., Shizuo Oi M.D. (eds.)
Distribution rights for Japan: Neuron Publishing Co., Tokyo, Japan
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Extra resources for Annual Review of Hydrocephalus: Volume 7 1989
Dye clearance test revealed that 4 of the 5 cases had disturbed absorption within 70% secretion into urine within 24 hours. Four responded favorably. Mean ICP values in all cases studied were lower than 15 mmHg, 4 of them showed frequent B waves and none showed A wave. Only 3 of the 4 cases with B wave responded to shunt. 46 mllmin. Cases with an average less than 120 mllday showed improvements in neurological findings after shunt. However, in cases of disturbed CSF absorption with 50% or less dye clearance, daily volume of CSF flowing in shunt tended to exceed 120 ml.
As the hydrocephalus continuously progressed, body weight and motor activity were rapidly decreased at the age of 4 weeks . When hydrocephalus was tre ated with V-P shunt at this age , the animals increased the ir food intakes from the following day and motor activity increased rapidly together with body weight. LCGU was decreased throughout the brain in hydrocephalus. Twenty to forty percent of the 26 Annual Review 0/ Hydrocephalus deerease was found in the cortex, with which a marked degree of subeortieal CSF edema was associated .
20 Annual Review of Hydrocephalus treated rats were sacrificed at 16 weeks and renal hypertensive ("clamped") rats at 22 weeks of age . Although our experimental tre atments produced significant changes in blood pressure, these changes did not alter brain ventricular size. SOs with renal hypertension had normal-sized brain ventricles and SHRs with pharmacologically reduced blood pressure had enlarged brain ventricles. The se results suggest that neither increased intr acerebroventricular pressure nor chronic high blood pressure is the sole cause of hydrocephalus in the SHRs.
Annual Review of Hydrocephalus: Volume 7 1989 by Mitsuru Wada (auth.), Satoshi Matsumoto M.D., Kiyoshi Sato M.D., Norihiko Tamaki M.D., Shizuo Oi M.D. (eds.)