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3 Evaluate the suitability, accuracy, and reliability of information from reference sources by explaining and evaluating the adequacy of experimental design and by applying and evaluating statistical tests and parameters. Basic Pharmacokinetics REV. 25 Copyright © 1996-1999 Michael C. 10 Pharmacokinetic Symbolism Pharmacokinetics was developed in several locations simultaneously. Because of this, the symbols used in the literature are not consistent. Provided each symbol is rigorously defined prior to use, this inconsistency should not prove an insurmountable difficulty when assessing the literature.

In fact 3 is a symbolic way of writing minus 3 (-3) for the characteristic. In every case the algebraic sum of the characteristic and the mantissa gives the correct value for the logarithm. 00713 ) Basic Pharmacokinetics REV. 25 Copyright © 1996-1999 Michael C. edu/pkinbook/ 2-9 Mathematics Review The reason for this symbolism is that only positive mantissa can be read from antilogarithmic tables, and hence a positive mantissa must be the end result of any logarithmic manipulations. , N) is determined only by inspection following the taking of anti-logarithms.

4. A shorthand notation (AEn) may be used, especially in scientific papers. 28 ×10 = 22800 Basic Pharmacokinetics REV. 25 Copyright © 1996-1999 Michael C. 3 SIGNIFICANT FIGURES A significant figure is any digit used to represent a magnitude or quantity in the place in which it stands. The digit may be zero (0) or any digit between 1 and 9. For example: TABLE 2-1. 0025 2,5 2 How do I determine the number of significant figures? Examples (c) to (e) illustrate the exceptions to the above general rule.

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Basic Pharmacokinetics by Michael C. Makoid, Ph.D., Phillip J. Vuchetich, Pharm.D., M.S., Umesh V. Banakar, Ph.D.

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