Download e-book for iPad: Bioreactor Systems for Tissue Engineering by D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr.

By D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. Cornelia Kasper, Prof. Martijn van Griensven, Dr. Ralf Pörtner (eds.)

ISBN-10: 3540693564

ISBN-13: 9783540693567

The editors of this unique quantity could first wish to thank all authors for his or her very good contributions. we might additionally wish to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for offering the chance to compose this quantity and Springer for organizational and technical aid. Tissue engineering represents one of many significant rising fields in glossy b- expertise; it combines varied topics starting from organic and fabric sciences to engineering and medical disciplines. the purpose of tissue engineering is the advance of healing methods to replacement diseased organs or tissues or increase their functionality. for that reason, 3 dimensional biocompatible fabrics are seeded with cells and cultivated in appropriate platforms to generate sensible tissues. many alternative points play a job within the formation of 3D tissue buildings. within the first position the resource of the used cells is of the maximum significance. to avoid tissue rejection or immune reaction, preferentially autologous cells at the moment are used. specifically, stem cells from assorted resources are gaining remarkable significance as they are often differentiated into diverse tissues by utilizing distinct media and supplementations. within the box of biomaterials, a variety of scaffold fabrics exist already yet new composites also are being constructed in accordance with polymeric, usual or xenogenic resources. furthermore, an important factor in tissue en- neering is the formation of tissues below good outlined, managed and reprod- ible stipulations. accordingly, a considerable variety of new bioreactors were developed.

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Mertsching, J. Hansmann This scaffold and bioreactor system may provide answers to the problem of bioartificial graft vascularisation, which is an inalienable prerequisite for the generation of clinically applicable bioartificial tissues and organs of sufficient strength and size. The first successful implantation of a tracheal patch has been published [19, 20]. 5 Cardiac Muscle Tissue Cardiac tissue engineering has emerged as a promising approach to replace or support an infracted cardiac tissue and thus may hold great potential to treat and save the lives of patients with heart disease.

It has been demonstrated that cyclic mechanical strain enhances the function and remodelling activity of smooth muscle cells. Additionally, cyclic strains significantly increased the mechanical strength and material modulus, as indicated by an increase in circumferential tensile properties of the constructs [7]. 26% of the full-scale output. 700% [4, 11]. Bioreactor Technology in Cardiovascular Tissue Engineering 33 Current studies demonstrate that the appropriate choice of a scaffold for vascular tissues in a mechanically dynamic environment depends on the time frame of the mechanical stimulation, and on elastic scaffolds allowing mechanically directed control of cellular function [11, 13].

12, 70569 Stuttgart, Germany 30 30 33 34 36 36 30 1 H. Mertsching, J. Hansmann Cardiovascular Tissue Engineering Cardiovascular diseases are a major cause of death in the Western world. In the past three decades there have been a number of improvements in artificial devices and surgical techniques for cardiovascular diseases; however, there is still a need for novel therapies. The major disadvantage of current artificial devices is that they cannot grow, remodel, or repair in vivo. Tissue engineering offers the possibility to develop autologous substitutes in vitro with the essential morphological, biological, chemical and mechanical properties [1].

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Bioreactor Systems for Tissue Engineering by D. Wendt, S. A. Riboldi, M. Cioffi, I. Martin (auth.), Dr. Cornelia Kasper, Prof. Martijn van Griensven, Dr. Ralf Pörtner (eds.)


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