By George Pettit
Cancer exacts an exceptionally harmful toll at the world's human populations. in recent times we now have often heard the expression "war on cancer," yet in comparison to the carnage inflicted by way of melanoma, our clinical and scientific efforts, so far, would appear extra like a minor skirmish. a few comprehension of the melanoma challenge will be acquired from a glance on the present and projected casualty record for the U.S.. during this nation, approximately 700,000 new circumstances of melanoma should be clinically determined in 1976 and over 1 million recognized instances will remain handled. Over 400,000 of those sufferers will die from melanoma in our bicentennial yr. With the occurrence of melanoma within the usa expanding to 5.2% in 1975, in comparison to the 1.1 % every year cost skilled for many years, Dr. F. J. Rauscher, Jr.,338 Director of the nationwide melanoma Institute, has predicted that greater than 10 million humans might be less than therapy for melanoma and approximately four million will expire from melanoma during this decade. At that price, melanoma will look in approximately of 3 households and the mandatory therapy will fee a few $15-20 billion in keeping with 12 months. therefore except tools for the therapy and keep an eye on of melanoma are markedly superior, approximately fifty three million american citizens now alive will finally be melanoma sufferers. Unfor tunately the key kinds of human melanoma are nonetheless past healing care through surgical and radiological options and thanks to the paucity of presently on hand melanoma chemotherapeutic medicinal drugs with healing potential.
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Extra info for Biosynthetic Products for Cancer Chemotherapy: Volume 1
Indeed some of this information still forms an integral part of traditional Chinese medical treatment, and a variety of plant extracts are currently in use as supportive measures for contemporary cancer treatment. S. Academy of Sciences medical and pharmacology delegation to the People's Republic of China in 1974, this writer was pleased to see that quotation prominently displayed in the Peking Institute of Materia Medica, where new cancer chemotherapeutic agents are being developed. C. ) may have been the first to use the word carcinoma.
Fortunately, because of the remarkable preservation and location 143 of these valuable accounts of primitive medicine and more recent collections, 143,144 we can estimate that more than 3,000 different plant species have found use in the primitive treatment of cancer. Many additional plant species are mentioned in letters written to the National Cancer Institute. These include some 600 letters received at the time of former Secretary of State John Foster Dulles's fatal struggle with cancer. D. 124 One of the first recorded attempts to use a single substance for cancer chemotherapy is attributed to Lissauer.
Such new biosynthetic products will also serve as useful starting points for further structural modification and the syntheses of potentially useful cancer chemotherapeutic drugs. 31 Introduction and Perspective 434 7 Cyclophosphamide (Cytoxan) LE TIC >300, PS TIC 250 Bl TIC 162, LL TIC 180 434 8 Isophosphamide LE TIC >300, PS TIC 300 Bl TIC 147, LL TIC 200 32 Chapter 1 434 (OCH,CH,),N -< )--CH,CH,CH,CO,H 9 Chloroambucil LE TIC 131, PS TIC 198 Bl TIC 132, LL inactive 434 10 N-Methyl nitrogen mustard (Mechlorethamine, mustargen) LE TIC 160, PS TIC 300 Bl TIC 185, LL inactive 33 Introduction and Perspective !
Biosynthetic Products for Cancer Chemotherapy: Volume 1 by George Pettit