By Frederick J. de Serres Ph.D. (auth.), Frederick J. De Serres, Michael D. Shelby (eds.)
Frederick J. de Serres, Ph. D. place of work of the affiliate Director for Genetics nationwide Institute of Environmental wellbeing and fitness Sciences examine Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was once orga nized to start the method of challenge id and determination relating our must overview the knowledge on try out chemical substances bobbing up from assays for mutagenic job on laboratory organisms. long ago, facts on chemical mutagens has been generated and released within the medical literature on a roughly random foundation. person chemical compounds get pleasure from a quick interval of "popularity" that ends up in a burst of guides within the similar or occasionally comparable assay structures. The incompleteness of the knowledge base, in lots of of those circumstances, makes comparative mutagenesis tough or very unlikely. In our makes an attempt to check the genetic results of a given chemical over quite a lot of assay platforms, we're usually attracted to making quantitative in addition to qualitative compari sons. To restate the 1st comparability: is the chemical below ques tion a vulnerable, average or effective mutagen over quite a lot of assay systems--or however, does the extent of reaction range markedly? To make the second one comparability, what's wanted is details at the spectrum of genetic changes produced in addition to even if this spectrum is constant over quite a lot of organisms.
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Anais Acad. Brasil Cancer Res. 36: 445-451 (1976). 26 CHAPTER 3 18. Kondo, S. (1968). Proe. 12th Internat1. Congr. Genet. 2: 126-127 19. Witkin, E. M. (1969). 20. , and Sugimura, T. 21. Slater, E. , Anderson, M. , Rosenkranz, H. S. Res. 31: 970-973 (1971). Proe. 12th Inter. Congr. Genet. 3: 225-245 Cancer Res. 32: 2369-2374 (1972). Cancer CHAPTER 4 MUTAGENICITY OF SELECTED CHEMICALS IN THE SALMONELLA/MICROSOME MUTAGENICITY TEST Lynne Haroun and Bruce N. Ames Department of Biochemistry, University of California at Berkeley, Berkeley, California 94720 The Salmonella/microsome mutagenicity test provides a simple, economical method for detecting chemical mutagens.
0 m -I -0 l> I (') OJ Salmonella/MICROSOME MUTAGEN ICITY TEST 1000 47 ETHYLENIMINE C1> "6 c::: 800 16 a.. g C1> > 400 C1> a:: 200 5 10 Ethylenimine (fLg) Figure 6. Mutagenicity of ethylenimine in the standard plate incorporation assay on~. typhimurium TA1535. Spontaneous revertant colonies have been subtracted. 7. Ethyl Methanesulfonate Ethyl methanesulfonate is a direct-acting mutagen in Salmonella, reverting the missense tester strains TA1535 and TAlOO (Table 6, Fig. 7). This compound has not been tested in the presence of S-9 or on the frameshift tester strain TA1537, although it is unlikely that this strain would be reverted by this chemical.
Comparative Chemical Mutagenesis by Frederick J. de Serres Ph.D. (auth.), Frederick J. De Serres, Michael D. Shelby (eds.)