By Jean-Philippe Doyon, Cedric Chauve, Sylvie Hamel (auth.), Craig E. Nelson, Stéphane Vialette (eds.)
This booklet constitutes the refereed complaints of the sixth RECOMB Comparative Genomics satellite tv for pc Workshop, RECOMB-CG 2008, held in Paris, France, in October 2008.
The 19 revised complete papers provided have been rigorously reviewed and chosen from forty eight preliminary submissions. The papers illustrate the an important function of comparative genomics in knowing genome functionality and handle a extensive number of facets, starting from the inference of evolution in genetic regulatory networks to the divergent fates of gene and genome duplication occasions and to the significance of latest computational techniques to unraveling the structural evolution of genomes.
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Extra info for Comparative Genomics: International Workshop, RECOMB-CG 2008, Paris, France, October 13-15, 2008. Proceedings
Proc. Natl. Acad. Sci. U S A 99, 13633–13635 (2002) Duplication Mechanism and Disruptions 37 3. , et al. : Construction and Analysis of a Human-chimpanzee Comparative Clone Map. Science 295, 131–134 (2002) 4. , et al. : Lineage-specific Gene Duplication and Loss in Human and Great Ape Evolution. PLoS Biol. 2, e207 (2004) 5. : Primate Segmental Duplications: Crucibles of Evolution, Diversity and Disease. Nat. Rev. Genet. 7(7), 552–564 (2006) 6. : The Evolution of Mammalian Gene Families. PLoS One 1, E85 (2006) 7.
For example, the Zhu et al.  study used the mouse genome to predict gene models of human pseudogenes. Though the divergence time between human and mouse is much greater than even the most distantly related Drosophila, the level of nucleotide divergence is equivalent to approximately the Dmel-Dyak split; comparing D. melanogaster and D. willistoni is equivalent to comparing the human genome to a lizard genome . It is obvious that pseudogene-based methods cannot be used beyond the limits of our ability to identify the homologs of pseudogenes, and it may simply be that they are inappropriate or less useful in rapidly evolving lineages.
8, r158 (2007) Duplication Mechanism and Disruptions 39 42. : An X-toautosome Retrogene Is Required for Spermatogenesis in Mice. Nat. Genet. 36, 872–876 (2004) 43. : The Temporal Distribution of Gene Duplication Events in a Set of Highly Conserved Human Gene Families. Mol. Biol. Evol. 20, 154–161 (2003) 44. : Estimating the Rate of Gene Conversion on Human Chromosome 21. Am. J. Hum. Genet. 75, 386–397 (2004) 45. : The Proteins of Linked Genes Evolve at Similar Rates. Nature 407, 900–903 (2000) 46.
Comparative Genomics: International Workshop, RECOMB-CG 2008, Paris, France, October 13-15, 2008. Proceedings by Jean-Philippe Doyon, Cedric Chauve, Sylvie Hamel (auth.), Craig E. Nelson, Stéphane Vialette (eds.)