By Armin Fiechter W. Babel (Editor), H. W. Blanch (Editor), C. Cooney (Editor), I. Endo (Editor)
ISBN-10: 3540677925
ISBN-13: 9783540677925
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Sample text
However, the immense importance of penicillin in the fight against several human bacterial infectious Advances in Biochemical Engineering/ Biotechnology, Vol. 70 Managing Editor: Th. Scheper © Springer-Verlag Berlin Heidelberg 2000 36 H. A. Knorre diseases soon became known. Penicillin-producing mold strains were sought in the environment and were cultivated in flat glass flasks such as Fernbach flasks. The use of Schott-borosilicatglass proved to be advantageous. It was found that the use of cheaper glass-types spoiled the synthesis of this antibiotic because of its arsenic content.
In: Scheper T, Schügerl K (eds) Adv Biochem Biotechnol 60 :125 19. Spohr A, Dam-Mikkelsen C, Carlsen M, Nielsen J, Villadsen J (1998) Biotechnol Bioeng 58 : 541 20. Schügerl K, Gerlach SR, Siedenberg D (1998) Adv Biochem Biotechnol 60 :195 21. Nielsen J, Johansen CL, Villadsen J (1994) J Biotechnol 38 : 51 22. Thiele EW (1939) Ind Eng Chem 31: 916 23. Rvesbech NP, Jørgensen BB, Brix O (1981) Limnol Oceanogr 26(4) : 717 24. Hooijmans CM (1990) Diffusion coupled with bioconversion in immobilized systems.
A great deal of effort was put in to erecting a production plant for penicillin attached to the Institute. As a result of the rapid increase in the size of the operation, the fermentation section of the Institute of Microbiology was named Jenapharm in 1947. To improve the unsatisfactory supply of medicines, other medicaments and drugs, such as vitamins, analgesics, and transfusion solutions were incorporated into its production program. The number of employees grew to more than 800. Finally, in 1950 the Institute of Microbiology became an independent nationally owned factory, the VEB Jenapharm (VEB means a state-owned company).
History of Modern Biotechnology II by Armin Fiechter W. Babel (Editor), H. W. Blanch (Editor), C. Cooney (Editor), I. Endo (Editor)
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