Download e-book for kindle: Hypocretins : integrators of physiological functions by Luis de Lecea; J Gregor Sutcliffe

By Luis de Lecea; J Gregor Sutcliffe

ISBN-10: 038725000X

ISBN-13: 9780387250007

The hypocretins (orexins) are a newly pointed out (1998) peptide family members created from peptides, hypocretin-1 and hypocretin-2. contemporary observations recommend an involvement of those peptides, situated basically within the hypothalmus, within the rules of behavioral kingdom. they're fascinated about circadian rhythms, metabolism, hormone secretion, physique temperature, urge for food, cardiovascular services (e.g., blood pressure), and sleep abnormalities (e.g., narcolepsy and cataplexy)

Show description

Read Online or Download Hypocretins : integrators of physiological functions PDF

Best nonfiction_7 books

Get Hardware-Software Co-Design of Embedded Systems: The POLIS PDF

Embedded platforms are informally outlined as a suite of programmable elements surrounded by means of ASICs and different regular elements, that engage consistently with an atmosphere via sensors and actuators. The programmable elements comprise micro-controllers and electronic sign Processors (DSPs). Embedded platforms are usually utilized in life-critical events, the place reliability and defense are extra vital standards than functionality.

Download e-book for kindle: Complex Systems in Biomedicine by M. Bertero, M. Piana (auth.), Alfio Quarteroni, Luca

Mathematical modeling of human physiopathology is a significantly bold job. It encompasses the modeling of such a lot different cubicles reminiscent of the cardiovascular, breathing, skeletal and worried platforms, in addition to the mechanical and biochemical interplay among blood movement and arterial partitions, or electrocardiac techniques and the electrical conduction into organic tissues.

Read e-book online Lithium Niobate: Defects, Photorefraction and Ferroelectric PDF

The ebook offers the present kingdom of reviews of element defects, either intrinsic and extrinsic (impurities, radiation facilities, and so on. ), in LiNbO3. The contribution of intrinsic defects to photoinduced cost delivery, i. e. to the photorefraction, is defined. The photorefractive and optical homes of LiNbO3 crystals with varied stoichiometry and of these doped with so-called "optical-damage resistant" impurities controlling the intrinsic disorder constitution are defined intimately.

Additional info for Hypocretins : integrators of physiological functions

Sample text

REM SLEEP-RELATED SYMPTOMS Characteristics of “abrupt arrests” were very different from those of quiet behavioral states with decreased overt activity, as well as from normal transitions into sleep. They were specifically recognized by the abrupt cessation of purposeful motor activity associated with sudden, sustained change in posture that was maintained throughout the episode, ending abruptly with complete resumption of purposeful motor activity (Fig. 2,5 Essentially, the episodes looked as if a behavioral switch had been turned “off” and then “on”.

Modified from ref. 5). RODENT MODELS OF HUMAN NARCOLEPSY-CATAPLEXY 33 EEG/EMG recordings concurrent with videotaping further differentiated gradual arrests from abrupt ones. As described above, abrupt arrests were accompanied either by direct transition from wakefulness to REM sleep or to the pre-REM stage with atonia in both orexin-/- and OX2R-/- mice (Fig. 2A). In contrast, EEG/EMG correlates of gradual arrests in both orexin-/- and OX2R-/- mice invariably revealed the onset of attenuated muscle tone, but not atonia, and an EEG transition from wakefulness to non-REM sleep (Fig.

OX1R is selective for orexin-A, whereas OX2R is a nonselective receptor for both orexin-A and orexin-B. 5. 10 These studies provide strong evidences for the roles of OX2R in regulating the vigilance state in human and animals. 9 Double receptor knockout (OX1R- and OX2R-null) mice appear to have the same phenotype of prepro-orexin knockout mice, suggesting that OX1R also has additional effects on sleep/wakefulness. These findings suggest that loss of signaling through both receptor pathways is necessary for emerging all of narcoleptic characteristics.

Download PDF sample

Hypocretins : integrators of physiological functions by Luis de Lecea; J Gregor Sutcliffe


by David
4.5

Rated 4.47 of 5 – based on 45 votes