Lean Biomanufacturing. Creating Value Through Innovative - download pdf or read online

By N.J. Smart (Auth.)

ISBN-10: 1907568786

ISBN-13: 9781907568787

ISBN-10: 1908818409

ISBN-13: 9781908818409

With lowering revenue margins, expanding price pressures, turning out to be regulatory compliance issues, mounting strain from conventional medications and extending anxiousness concerning the way forward for healthcare compensation, pharmaceutical brands at the moment are compelled to re-evaluate and re-assess the best way they've been doing issues. so as to maintain profitability, those businesses want to decrease waste (of all kinds), enhance potency and raise productiveness. lots of them are taking a better examine lean production which will in achieving those objectives. Lean biomanufacturing re-visits lean rules after which applies them sympathetically - in a hugely sensible procedure - to the categorical wishes of pharmaceutical tactics, which current considerably various demanding situations to extra mainstream production approaches. an important objective of the booklet is to focus on these difficulties and concerns that seem extra particular or specified to biopharmaceutical production occasions and to supply a few insights into what demanding situations are the $64000 ones to resolve and what recommendations, instruments and mechanisms to hire to be successful.

Following an advent to lean biomanufacturing, the ebook is going directly to speak about lean applied sciences and techniques utilized in biomanufacturing. Later chapters hide the construction and implementation of the Transition Plan, matters dealing with the biopharmaceutical undefined, making a lean strategy in the direction of biopharmaceutical procedures and the contribution of simulation versions in constructing those techniques. the ultimate bankruptcy covers examples of latest know-how thoughts which support facilitate lean biomanufacturing.

  • A concentrate on the problems linked to the appliance of lean ideas to biomanufacturing
  • Practical examples of things which could impact biopharmaceutical processes
  • Coverage of key elements which require integration to run an effective biopharmaceutical process

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Additional info for Lean Biomanufacturing. Creating Value Through Innovative Bioprocessing Approaches

Sample text

For each event. The final piece of the anatomy is the scoring card where all the key/ relevant information is collected and displayed for analysis. During the review process and during any ongoing scorecard analysis, this will be a point of focus for metric information during performance evaluation. 2 illustrates a typical value stream map key parameters box and how one might expect to see it as a representation on a value stream map. 2 Box score The box score is a summary chart which records key performance measures for the process being studied.

Also in the same way that Lean continuously works to reduce costs it applies the same approach to reduce variability in the pursuit of the perfect process solution. TOC, on the other hand, once again assumes the diminishing returns approach to continuous process improvement and at a certain point shows that further effort is not a sound return on the investment of effort. 26 Published by Woodhead Publishing Limited, 2013 An introduction to Lean biomanufacturing Although the two methodologies emphasize different routes to the same goal, where Lean emphasizes cost reduction and a high level of efficiency and TOC emphasizes high throughput, both present possibilities for routes to transform manufacturing of biopharmaceuticals.

5 Mistake-proofing (Poke Yoke) In processing industries like biotechnology where material flow requires input from both machines and human beings, there will always be mistakes, defects and errors introduced into the mix. To think otherwise is to be unrealistic since both have their respective frailties. The important goal to define and focus on is in relation to error reduction to a point where, to all intents and purposes, it has been eliminated. Aligned with 12 Published by Woodhead Publishing Limited, 2013 An introduction to Lean biomanufacturing this point is the goal of doing things correct (or right) first time.

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Lean Biomanufacturing. Creating Value Through Innovative Bioprocessing Approaches by N.J. Smart (Auth.)


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