Download PDF by Andrey S. Simbirtsev, Ivan G. Kozlov (auth.), Andre Kamkin,: Mechanical Stretch and Cytokines

By Andrey S. Simbirtsev, Ivan G. Kozlov (auth.), Andre Kamkin, Irina Kiseleva (eds.)

ISBN-10: 9400720033

ISBN-13: 9789400720039

This ebook offers the newest findings within the box of research of molecular mechanisms of mechanical stretch and the function of cytokines in reaction of other tissues to it. at the one hand this quantity demonstrates how mechanical stretch complements cytokines construction. It describes how cytokines effect tissues and cells on a heritage of a mechanical stretching. It offers an outline of ways cells in several tissues are activated by way of stretch and cytokines through numerous signaling pathways, and the way they modify their gene expression. The publication is a distinct selection of reports outlining present wisdom and destiny advancements during this quickly becoming box. wisdom of biomechanics, and mechanisms which underlie it on molecular, mobile and tissue, is important for knowing of the traditional functioning of dwelling organisms and permits to foretell adjustments, which come up because of changes in their environment.

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Additional info for Mechanical Stretch and Cytokines

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Both chemokines with short range action and chemokines with broad spectrum of functions exist, and several chemokines often affect the same cells. The most numerous chemokine subclass is CC. The main function of these chemokines is chemotactic activation of predominantly monocytes/macrophages, lymphocytes, basophiles and eosinophils. Two members of the third subclass, C chemokines, are chemoattractive for T-lymphocytes. They are synthesized by T-lymphocytes, NK-cells, mast cells, and their unique characteristic is quite selective action on lymphocytes only.

Kozlov IL-17A receptors consist from two subunits that are typical transmembrane polypeptides interacting for signal transduction after binding with cytokine. After IL-17A binding with receptors intracellular molecular cascade is activated which leads to activation of transcriptional factors NF-κB, AP-1, and also some kinases (ERK, c-Jun N-terminal kinase and p38 MAP kinase). , 2006). IL-17A is synthesized predominantly by antigen-activated T-lymphocytes and acts on innate immune cells: monocytes/macrophages and neutrophils, stimulating IL-1, TNF, IL-6, G-CSF, chemokine and antimicrobial peptide production.

The first is formed if two p40 polypeptides are bound and homodimeric variant IL-12p80 is produced that have similar to IL-12p70 biological activity but is rarely found. , 2007). Its biological functions include stimulation of T-regulatory lymphocytes (Treg) differentiation and restriction of IL-17 induced inflammation development. Gene expression and all cytokines from IL-12 family production predominantly occur in dendritic cells and macrophages in response to different pathogens after interaction between pathogen-associated molecular patterns with cellular Toll-like receptors (Trinchieri, 2003).

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Mechanical Stretch and Cytokines by Andrey S. Simbirtsev, Ivan G. Kozlov (auth.), Andre Kamkin, Irina Kiseleva (eds.)

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