By Warner C. Greene, Richard J. Robb (auth.), Steven Gillis, F. P. Inman (eds.)
Investigations of the activation, proliferation, and, on occasion, differentia tion of mononuclear cells inquisitive about the immune reaction are continuing speedily. those reports have ended in the invention of numerous components that advertise those mobile occasions, a few of that have been characterised biochemically to varied extents. as a result enormous curiosity in figuring out those mobile alterations on the molecular point, we selected to provide the 1st thematic quantity for modern issues in Molecular Immunology; the subject matter bargains with convinced regulatory elements that advertise proliferation and differentiation. we have now com piled contributions from a number of scientists renowned for his or her paintings with numerous regulatory elements. within the following paragraphs, the reader will locate an outline of the contents of this quantity. Greene and Robb evaluation info they've got generated during the last 2-3 years with recognize to characterization of hormone-specific Interleukin-2 (IL-2) recep tors at the floor of activated T cells. Their bankruptcy strains the advance of a quantitative assay for review of IL-2 receptors in response to the training and use of radiolabeled IL-2 ready biosynthetically by using IL-2-pro ducer leukemic cells. The authors then describe another strategy, the prep aration of a monoclonal antibody formerly decided to be directed opposed to a T -cell-activation antigen. This so-called anti-Tac antibody was once later came across to acknowledge a determinant on or close to the IL-2 receptor.
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C. Greene, unpublished data). Addition of purified TCGF to cultures of HCL cells, however, produced only a two- to three-fold increase in thymidine incorporation measured at 48 hr and did not support the long-term growth of these cells. Thus, expression of the Tac antigen in this leukemia may simply reflect transformationassociated expression of an inappropriate gene product. J U. ~~c 51gTAC8% + 1% FLUORESCENCE (TAC) Figure 8. Linear contour plot of two-color, dual fluorescence comparison of hairy cell leukemia cells stained with FITC-anti-Tac and biotinylated anti-human X-chain monoclonal antibody followed by avidin-linked Texas Red.
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Using purified HTLV I virions, these investigators found that Tac antigen expression markedly exceeded that of other cell-surface markers, including Leu-1, HLA-Dr, T4, T9, and the sheep red blood cell rosette receptor. One interpretation of these findings is that the Tac antigen becomes associated with the virion during the viral budding process. , 1982). Furthermore, specific cell-surface binding sites for enveloped viruses, as visualized by electron microscopy, were shown to frequently occur at or near sites of virus budding (Miyamoto and Gilden, 1971).
The Interleukins by Warner C. Greene, Richard J. Robb (auth.), Steven Gillis, F. P. Inman (eds.)