By Janice S. Dorman PhD, Ronald E. LaPorte PhD, Thomas J. Songer PhD (auth.), Mark A. Sperling MD (eds.)
The expanding occurrence of diabetes all over the world has caused a quick progress within the speed of medical discovery and scientific figuring out of this enigmatic disorder. In variety 1 Diabetes: Etiology and therapy, well-recognized physicians and researchers evaluation the most recent considering the explanations of this and the simplest techniques to treating either its acute and persistent problems. The therapies mentioned diversity from life-threatening diabetic ketoacidosis to modern insulin regimens, from open- and closed-loop insulin supply units to fashionable glucose-sensing mechanisms, in addition to such way of life matters as food and schooling. additionally mentioned are the administration of kids lower than the age of 5, the detailed difficulties of preadolescents and youth, diabetic surgical procedure, and being pregnant, in addition to the remedy and prevention of the long term vascular issues that produce coronary artery ailment, the lack of limbs, end-stage renal disorder, and blindness. The authors pay particular awareness to explaining the molecular foundation of diabetes and its problems, in addition to to the numerous contemporary advancements in complete pancreas and islet cellphone transplantation, together with the potential for fending off the rejection of transplanted islets.
Authoritative and updated, kind 1 Diabetes: Etiology and therapy presents all these taking good care of diabetic sufferers with a concise, available survey of cutting-edge most sensible pondering the motives, remedy, and administration of this advanced disease.
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Additional info for Type 1 Diabetes: Etiology and Treatment
Diabetes Metab Res Rev 1999;15:353-361. 94. Paronen J, Knip M, Savilahti E, et al. Effect of cow's milk exposure and maternal type I diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type I diabetes. Diabetes 2000;49: 1657-1665. 95. Vaarala 0, Knip M, Paronen J, et al. Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type! diabetes. Diabetes 1999;48: 1389-1394. 96. Saukkonen T, Virtanen SM, Karppinen M, et al.
Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N Eng! J Med 1993;329: 1853-1858. 87. Norris JM, Beaty B, Klingensmith G, et al. Lack of association between early exposure to cow's milk protein and ~-cell autoimmunity. JAMA 1996;276:609-614. 88. Couper JJ, Steele C, Beresford S, et al. Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity. Diabetes 1999;48:2145-2149. 89. Virtanen SM, Uiara E, Hypponen E, et al.
The importance of class II molecules in playing a role in the pathogenesis of T1 DM is also indicated by studies in a transgenic NOD mouse model, in which the expression of an 1-A (the equivalent to the human class II DQB 1 locus) ~-chain transgene carrying Asp 57 instead of Ser 57 protects these mice from developing diabetes ( 128, 129). Moreover, expression of Pro56 instead of the normal His56 in the 1-A a-chain has the same effect ( 130). Finally, expression of certain 1-E (the equivalent of the human HLADR locus) transgenes appears to confer resistance to the disease (130,131 ).
Type 1 Diabetes: Etiology and Treatment by Janice S. Dorman PhD, Ronald E. LaPorte PhD, Thomas J. Songer PhD (auth.), Mark A. Sperling MD (eds.)